Infected Cell Killing by HIV-1 Protease Promotes NF-κB Dependent HIV-1 Replication

Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1. Given the independent observations that acute T cell HIV-1 infection results in (1) NF-κB activation, (2) caspase 8 dependent apoptosis, and th...

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Detalhes bibliográficos
Main Authors: Bren, Gary D., Whitman, Joe, Cummins, Nathan, Shepard, Brett, Rizza, Stacey A., Trushin, Sergey A., Badley, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346551/
https://ncbi.nlm.nih.gov/pubmed/18461165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002112
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