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Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection

In schistosomiasis mansoni, parasite eggs cause hepatointestinal granulomatous inflammation and fibrosis mediated by CD4 T cells specific for egg antigens. The severity of disease varies extensively in humans and among mouse strains. Marked disease exacerbation induced in typically low-pathology C57...

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Detalhes bibliográficos
Main Authors: Shainheit, Mara G., Saraceno, Rosita, Bazzone, Lindsey E., Rutitzky, Laura I., Stadecker, Miguel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932859/
https://ncbi.nlm.nih.gov/pubmed/17403877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01053-06
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