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T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17 cell-mediated inflammation

C57BL/6 mice infected with Schistosoma mansoni naturally develop mild CD4(+) T cell-mediated immunopathology characterized by small hepatic granulomas around parasite eggs. However, immunization with soluble egg antigens in CFA (SEA/CFA) markedly exacerbates the lesions by inducing a potent proinfla...

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書誌詳細
主要な著者: Rutitzky, Laura I., Smith, Patrick M., Stadecker, Miguel J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024243/
https://ncbi.nlm.nih.gov/pubmed/19714576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939325
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