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T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17 cell-mediated inflammation
C57BL/6 mice infected with Schistosoma mansoni naturally develop mild CD4(+) T cell-mediated immunopathology characterized by small hepatic granulomas around parasite eggs. However, immunization with soluble egg antigens in CFA (SEA/CFA) markedly exacerbates the lesions by inducing a potent proinfla...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024243/ https://ncbi.nlm.nih.gov/pubmed/19714576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939325 |
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