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Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection

In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for schistosome egg antigens (SEA). In the mouse model of the disease, CBA mi...

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書誌詳細
主要な著者: Rutitzky, Laura I., Hernandez, Hector J., Stadecker, Miguel J.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC60855/
https://ncbi.nlm.nih.gov/pubmed/11606762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231258498
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