Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection

In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for schistosome egg antigens (SEA). In the mouse model of the disease, CBA mi...

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Hlavní autoři: Rutitzky, Laura I., Hernandez, Hector J., Stadecker, Miguel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC60855/
https://ncbi.nlm.nih.gov/pubmed/11606762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231258498
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