Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection

In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for schistosome egg antigens (SEA). In the mouse model of the disease, CBA mi...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rutitzky, Laura I., Hernandez, Hector J., Stadecker, Miguel J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60855/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.231258498
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