Disruption of the ICOS-B7RP-1 Costimulatory Pathway Leads to Enhanced Hepatic Immunopathology and Increased Gamma Interferon Production by CD4 T Cells in Murine Schistosomiasis

Morbidity and mortality in schistosomiasis are largely due to an immune response mediated by CD4 T lymphocytes. Since lymphocyte activation is shaped by costimulatory signals, the specific functions of different costimulatory pathways are of increasing interest. We now examined the role of the induc...

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Detalhes bibliográficos
Main Authors: Rutitzky, Laura I., Özkaynak, Engin, Rottman, James B., Stadecker, Miguel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC161982/
https://ncbi.nlm.nih.gov/pubmed/12819093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.4040-4044.2003
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