Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, I(Kr). This study investigated the effects on HERG channels of doxepin, a tricyclic antidepressant linked to QT interval prolongation and cardiac arrhythmia. Whole-cell pat...

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Main Authors: Duncan, R.S., McPate, M.J., Ridley, J.M., Gao, Z., James, A.F., Leishman, D.J., Leaney, J.L., Witchel, H.J., Hancox, J.C.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920586/
https://ncbi.nlm.nih.gov/pubmed/17560554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.04.024
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