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Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin
HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, I(Kr). This study investigated the effects on HERG channels of doxepin, a tricyclic antidepressant linked to QT interval prolongation and cardiac arrhythmia. Whole-cell pat...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920586/ https://ncbi.nlm.nih.gov/pubmed/17560554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.04.024 |
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