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Pharmacology of the short QT syndrome N588K-hERG K(+) channel mutation: differential impact on selected class I and class III antiarrhythmic drugs
BACKGROUND AND PURPOSE: The short QT syndrome (SQTS) is associated with cardiac arrhythmias and sudden death. The SQT1 form of SQTS results from an inactivation-attenuated, gain-of-function mutation (N588K) to the human ether-à-go-go-related gene (hERG) potassium channel. Pharmacological blockade of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597231/ https://ncbi.nlm.nih.gov/pubmed/18724381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.325 |
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