Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Congenital short QT syndrome (SQTS) is a repolarization disorder characterized by abbreviated QT intervals, atrial and ventricular arrhythmias and a risk of sudden death. This study characterized a missense mutation (I560T) in the S5 domain of the hERG K(+) channel that has been associated with vari...

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Publicado en:Heliyon
Autores principales: Butler, Andrew, Zhang, Yihong, Stuart, A. Graham, Dempsey, Christopher E., Hancox, Jules C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479114/
https://ncbi.nlm.nih.gov/pubmed/31049424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e01429
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