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Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

The hERG potassium channel is critical to normal repolarization of cardiac action potentials (APs) and loss‐ and gain‐of‐function hERG mutations are associated, respectively, with long and short QT syndromes, pathological conditions that can lead to arrhythmias and sudden death. hERG current (I (h)...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Butler, Andrew, Zhang, Yihong, Stuart, Alan G., Dempsey, Christopher E., Hancox, Jules C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119704/
https://ncbi.nlm.nih.gov/pubmed/30175559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13845
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