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Pharmacology of the short QT syndrome N588K-hERG K(+) channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

BACKGROUND AND PURPOSE: The short QT syndrome (SQTS) is associated with cardiac arrhythmias and sudden death. The SQT1 form of SQTS results from an inactivation-attenuated, gain-of-function mutation (N588K) to the human ether-à-go-go-related gene (hERG) potassium channel. Pharmacological blockade of...

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Autori principali: McPate, M J, Duncan, R S, Hancox, J C, Witchel, H J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597231/
https://ncbi.nlm.nih.gov/pubmed/18724381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.325
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