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A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

In this work we develop a microscopic physical model of early evolution where phenotype—organism life expectancy—is directly related to genotype—the stability of its proteins in their native conformations—which can be determined exactly in the model. Simulating the model on a computer, we consistent...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Zeldovich, Konstantin B, Chen, Peiqiu, Shakhnovich, Boris E, Shakhnovich, Eugene I
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914367/
https://ncbi.nlm.nih.gov/pubmed/17630830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030139
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