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Protein stability imposes limits on organism complexity and speed of molecular evolution

Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study population dynamics in a model where fitness can be inferred from physical properties of proteins under a physiological assump...

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Bibliografiske detaljer
Main Authors: Zeldovich, Konstantin B., Chen, Peiqiu, Shakhnovich, Eugene I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042177/
https://ncbi.nlm.nih.gov/pubmed/17913881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705366104
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