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A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

In this work we develop a microscopic physical model of early evolution where phenotype—organism life expectancy—is directly related to genotype—the stability of its proteins in their native conformations—which can be determined exactly in the model. Simulating the model on a computer, we consistent...

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Détails bibliographiques
Auteurs principaux: Zeldovich, Konstantin B, Chen, Peiqiu, Shakhnovich, Boris E, Shakhnovich, Eugene I
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914367/
https://ncbi.nlm.nih.gov/pubmed/17630830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030139
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