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Substrate inhibition imposes fitness penalty at high protein stability
Proteins are only moderately stable. It has long been debated whether this narrow range of stabilities is solely a result of neutral drift toward lower stability or purifying selection against excess stability—for which no experimental evidence was found so far—is also at work. Here, we show that mu...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561296/ https://ncbi.nlm.nih.gov/pubmed/31097595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821447116 |
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