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Optimization of lag phase shapes the evolution of a bacterial enzyme
Mutations provide the variation that drives evolution, yet their effects on fitness remain poorly understood. Here we explore how mutations in the essential enzyme Adenylate Kinase (Adk) of E. coli affect multiple phases of population growth. We introduce a biophysical fitness landscape for these ph...
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| Опубликовано в: : | Nat Ecol Evol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5640271/ https://ncbi.nlm.nih.gov/pubmed/28812634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-017-0149 |
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