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New Insights into Vitamin D Sterol-VDR Proteolysis, Allostery, Structure-Function from the Perspective of a Conformational Ensemble Model
Recently, we have developed a vitamin D sterol (VDS)-VDR conformational ensemble model. This model can be broken down into three individual, yet interlinked parts: a) the conformationally flexible VDS, b) the apo/holo-VDR helix-12 (H12) conformational ensemble, and c) the presence of two VDR ligand...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1906717/ https://ncbi.nlm.nih.gov/pubmed/17368177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.004 |
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