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New Insights into Vitamin D Sterol-VDR Proteolysis, Allostery, Structure-Function from the Perspective of a Conformational Ensemble Model

Recently, we have developed a vitamin D sterol (VDS)-VDR conformational ensemble model. This model can be broken down into three individual, yet interlinked parts: a) the conformationally flexible VDS, b) the apo/holo-VDR helix-12 (H12) conformational ensemble, and c) the presence of two VDR ligand...

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Detalhes bibliográficos
Main Authors: Mizwicki, Mathew T., Bula, Craig M., Bishop, June E., Norman, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906717/
https://ncbi.nlm.nih.gov/pubmed/17368177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.004
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