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A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implications

Molecular modeling results indicate that the VDR contains two overlapping ligand binding pockets (LBP). Differential ligand stability and fractional occupancy of the two LBP has been physiochemically linked to the regulation of VDR-dependent genomic and non-genomic cellular responses. The purpose of...

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Bibliografiset tiedot
Päätekijät: Mizwicki, Mathew T., Menegaz, Danusa, Yaghmaei, Sepideh, Henry, Helen L., Norman, Anthony W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921884/
https://ncbi.nlm.nih.gov/pubmed/20398762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2010.04.005
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