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Solution NMR Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveals a Dynamic Helix in the Ligand-Binding Pocket

The ligand-binding domains (LBD) of the NR5A subfamily of nuclear receptors activate transcription via ligand-dependent and ligand-independent mechanisms. The Drosophila Ftz-F1 receptor (NR5A3) belongs to the latter category and its ligand-independence is attributed to a short helical segment (α6) w...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Daffern, Nicolas, Chen, Zhonglei, Zhang, Yongbo, Pick, Leslie, Radhakrishnan, Ishwar
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882526/
https://ncbi.nlm.nih.gov/pubmed/29547262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00069
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