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Conservative Mutageneic Perturbations of Amino Acids Connecting Helix 12 in the 1α,25(OH)(2)-D(3) Receptor (VDR) to the Ligand Cause Significant Transactivational Effects
The positioning of helix 12 activation domain of nuclear receptor proteins is critically important for gene regulation. Perturbations of the helix 12 by larger analogs may alter interactions with transcriptional machinery which might give rise to selectivity. To explore the topology of the ligand bi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920180/ https://ncbi.nlm.nih.gov/pubmed/17368178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2006.12.043 |
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