Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity

NOD mice with knockout of both native insulin genes and a mutated proinsulin transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not develop diabetes. Transplantation of NOD islets, but not bone marrow, expressing native insulin sequences (tyrosine at position B16) into B16:A-dK...

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Detalhes bibliográficos
Main Authors: Nakayama, Maki, Beilke, Joshua N., Jasinski, Jean M., Kobayashi, Masakazu, Miao, Dongmei, Li, Marcella, Coulombe, Marilyne G., Liu, Edwin, Elliott, John F., Gill, Ronald G., Eisenbarth, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904318/
https://ncbi.nlm.nih.gov/pubmed/17607359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31368
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