Conserved T cell receptor α-chain induces insulin autoantibodies

A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9–23 peptide sequence in type 1 diabetes. Anti-insulin B:9–23 T cell clones isolated from prediabetic NOD islets have a...

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Hlavní autoři: Kobayashi, Masakazu, Jasinski, Jean, Liu, Edwin, Li, Marcella, Miao, Dongmei, Zhang, Li, Yu, Liping, Nakayama, Maki, Eisenbarth, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2464615/
https://ncbi.nlm.nih.gov/pubmed/18626021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801648105
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