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Allelic Variation in the Hepatitis C Virus NS4B Protein Dramatically Influences RNA Replication

In the Huh-7.5 hepatoma cell line, replication of the genotype 1a H77 strain of hepatitis C virus (HCV) is attenuated compared to that of the genotype 1b Con1 strain. This study identifies the poorly characterized integral membrane protein, NS4B, as a major determinant for this replication differenc...

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Bibliografske podrobnosti
Glavni avtor: Blight, Keril J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900245/
https://ncbi.nlm.nih.gov/pubmed/17360748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02481-06
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