A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

We previously demonstrated that two closely spaced polyproline motifs, with the consensus sequence Pro-X-X-Pro-X-Lys/Arg, located between residues 343 to 356 of NS5A, mediated interactions with cellular SH3 domains. The N-terminal motif (termed PP2.1) is only conserved in genotype 1 isolates, wherea...

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Detalhes bibliográficos
Main Authors: Hughes, Mair, Gretton, Sarah, Shelton, Holly, Brown, David D., McCormick, Christopher J., Angus, Allan G. N., Patel, Arvind H., Griffin, Stephen, Harris, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753128/
https://ncbi.nlm.nih.gov/pubmed/19656877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02406-08
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