Intragenic Complementation of Hepatitis C Virus NS5A RNA Replication-Defective Alleles

Hepatitis C virus NS5A has three structural domains, is required for RNA replication and virion assembly, and exists in hypo- and hyperphosphorylated forms. Accumulated data suggest that phosphorylation is involved in modulating NS5A functions. We performed a mutational analysis of highly conserved...

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Detalhes bibliográficos
Principais autores: Fridell, Robert A., Valera, Lourdes, Qiu, Dike, Kirk, Melissa J., Wang, Chunfu, Gao, Min
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571461/
https://ncbi.nlm.nih.gov/pubmed/23236071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02861-12
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