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Allelic Variation in the Hepatitis C Virus NS4B Protein Dramatically Influences RNA Replication
In the Huh-7.5 hepatoma cell line, replication of the genotype 1a H77 strain of hepatitis C virus (HCV) is attenuated compared to that of the genotype 1b Con1 strain. This study identifies the poorly characterized integral membrane protein, NS4B, as a major determinant for this replication differenc...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1900245/ https://ncbi.nlm.nih.gov/pubmed/17360748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02481-06 |
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