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Primary Human Immunodeficiency Virus Type 1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice

We previously reported that the human immunodeficiency virus type 1 NL4-3 Nef is necessary and sufficient to induce a severe AIDS-like disease in transgenic (Tg) mice when the protein is expressed under the regulatory sequences of the human CD4 gene. We have now assayed additional Nef alleles (SF2,...

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Autors principals: Priceputu, Elena, Hanna, Zaher, Hu, Chunyan, Simard, Marie-Chantal, Vincent, Patrick, Wildum, Steffen, Schindler, Michael, Kirchhoff, Frank, Jolicoeur, Paul
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900134/
https://ncbi.nlm.nih.gov/pubmed/17314161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02691-06
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