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CD4(+) T Cells from CD4C/HIV(Nef) Transgenic Mice Show Enhanced Activation In Vivo with Impaired Proliferation In Vitro but Are Dispensable for the Development of a Severe AIDS-Like Organ Disease
The cellular and molecular mechanisms of dysfunction and depletion of CD4(+) T lymphocytes over the course of human immunodeficiency virus type 1 (HIV-1) infection are still incompletely understood, but chronic immune activation is thought to play an important role in disease progression. We studied...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC400335/ https://ncbi.nlm.nih.gov/pubmed/15113906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.10.5244-5257.2004 |
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