CD4(+) T Cells from CD4C/HIV(Nef) Transgenic Mice Show Enhanced Activation In Vivo with Impaired Proliferation In Vitro but Are Dispensable for the Development of a Severe AIDS-Like Organ Disease

The cellular and molecular mechanisms of dysfunction and depletion of CD4(+) T lymphocytes over the course of human immunodeficiency virus type 1 (HIV-1) infection are still incompletely understood, but chronic immune activation is thought to play an important role in disease progression. We studied...

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Publié dans:	J Virol
Auteurs principaux:	Weng, Xiaoduan, Priceputu, Elena, Chrobak, Pavel, Poudrier, Johanne, Kay, Denis G., Hanna, Zaher, Mak, Tak W., Jolicoeur, Paul
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2004
Sujets:	Pathogenesis and Immunity
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15113906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.10.5244-5257.2004
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