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Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease

We have constructed transgenic (Tg) mice expressing the entire human immunodeficiency virus type 1 (HIV-1) coding sequences in cells targeted by HIV-1 infection in humans. These Tg mice developed a severe AIDS-like disease leading to early death (<1 month). They developed muscle wasting, severe atro...

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Udgivet i:J Virol
Principais autores: Hanna, Zaher, Kay, Denis G., Cool, Marc, Jothy, Serge, Rebai, Najet, Jolicoeur, Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Viral Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109356/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9420207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.1.121-132.1998
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