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Selective Expression of Human Immunodeficiency Virus Nef in Specific Immune Cell Populations of Transgenic Mice Is Associated with Distinct AIDS-Like Phenotypes

We previously reported that CD4C/human immunodeficiency virus (HIV)(Nef) transgenic (Tg) mice, expressing Nef in CD4(+) T cells and cells of the macrophage/dendritic cell (DC) lineage, develop a severe AIDS-like disease, characterized by depletion of CD4(+) T cells, as well as lung, heart, and kidne...

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Bibliographic Details
Main Authors: Hanna, Zaher, Priceputu, Elena, Chrobak, Pavel, Hu, Chunyan, Dugas, Véronique, Goupil, Mathieu, Marquis, Miriam, de Repentigny, Louis, Jolicoeur, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748029/
https://ncbi.nlm.nih.gov/pubmed/19605470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00125-09
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