The Nef-Mediated AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Increased Fas/FasL Expression on T Cells and T-Cell Death but Is Not Prevented in Fas-, FasL-, Tumor Necrosis Factor Receptor 1-, or Interleukin-1β-Converting Enzyme-Deficient or Bcl2-Expressing Transgenic Mice

CD4(+)- and CD8(+)-T-cell death is a frequent immunological dysfunction associated with the development of human AIDS. We studied a murine model of AIDS, the CD4C/HIV transgenic (Tg) mouse model, to assess the importance of the apoptotic pathway in human immunodeficiency virus type 1 (HIV-1) pathoge...

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Detalhes bibliográficos
Main Authors: Priceputu, Elena, Rodrigue, Isabelle, Chrobak, Pavel, Poudrier, Johanne, Mak, Tak W., Hanna, Zaher, Hu, Chunyan, Kay, Denis G., Jolicoeur, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091671/
https://ncbi.nlm.nih.gov/pubmed/15858021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.6377-6391.2005
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