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Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4(+) T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia
CD4C/HIV(nef) transgenic (Tg) mice express Nef in CD4(+) T cells and in the cells of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease similar to human AIDS. In these mice, Nef is constitutively expressed throughout life. To rule out the contribution of any development...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology (ASM)
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772706/ https://ncbi.nlm.nih.gov/pubmed/19740990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01466-09 |
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