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Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4(+) T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia

CD4C/HIV(nef) transgenic (Tg) mice express Nef in CD4(+) T cells and in the cells of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease similar to human AIDS. In these mice, Nef is constitutively expressed throughout life. To rule out the contribution of any development...

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Autors principals: Rahim, Mir Munir Ahmed, Chrobak, Pavel, Hu, Chunyan, Hanna, Zaher, Jolicoeur, Paul
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772706/
https://ncbi.nlm.nih.gov/pubmed/19740990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01466-09
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