Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.

An abnormal isoform of the prion protein (PrP) designated PrPSc is the major, or possibly the only, component of infectious prions. Structural studies of PrPSc have been impeded by its lack of solubility under conditions in which infectivity is retained. Among the many detergents examined, only trea...

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Bibliografiske detaljer
Main Authors: Riesner, D, Kellings, K, Post, K, Wille, H, Serban, H, Groth, D, Baldwin, M A, Prusiner, S B
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC189995/
https://ncbi.nlm.nih.gov/pubmed/8627692
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