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Immunoaffinity purification and neutralization of scrapie prion infectivity.

Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the scrapie isoform of the prion protein (PrPSc) is a major component of the prion. Limited proteinase K digestion of PrPSc produced...

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Autors principals: Gabizon, R, McKinley, M P, Groth, D, Prusiner, S B
Format: Artigo
Idioma:Inglês
Publicat: 1988
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC282028/
https://ncbi.nlm.nih.gov/pubmed/3137571
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