Immunoaffinity purification and neutralization of scrapie prion infectivity.

Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the scrapie isoform of the prion protein (PrPSc) is a major component of the prion. Limited proteinase K digestion of PrPSc produced...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Gabizon, R, McKinley, M P, Groth, D, Prusiner, S B
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1988
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282028/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3137571/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.18.6617
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