Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.

An abnormal isoform of the prion protein (PrP) designated PrPSc is the major, or possibly the only, component of infectious prions. Structural studies of PrPSc have been impeded by its lack of solubility under conditions in which infectivity is retained. Among the many detergents examined, only trea...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Riesner, D, Kellings, K, Post, K, Wille, H, Serban, H, Groth, D, Baldwin, M A, Prusiner, S B
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1714-1722.1996
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