Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

By comparing the amino acid sequences of 11 mammalian and 1 avian prion proteins (PrP), structural analyses predicted four alpha-helical regions. Peptides corresponding to these regions of Syrian hamster PrP were synthesized, and, contrary to predictions, three of the four spontaneously formed amylo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gasset, M, Baldwin, M A, Lloyd, D H, Gabriel, J M, Holtzman, D M, Cohen, F, Fletterick, R, Prusiner, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10940
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