Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

By comparing the amino acid sequences of 11 mammalian and 1 avian prion proteins (PrP), structural analyses predicted four alpha-helical regions. Peptides corresponding to these regions of Syrian hamster PrP were synthesized, and, contrary to predictions, three of the four spontaneously formed amylo...

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Bibliografiske detaljer
Main Authors: Gasset, M, Baldwin, M A, Lloyd, D H, Gabriel, J M, Holtzman, D M, Cohen, F, Fletterick, R, Prusiner, S B
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC50458/
https://ncbi.nlm.nih.gov/pubmed/1438300
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