Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational process, no candidate chemical modification was identified, suggesting that a conformational change features i...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Pan, K M, Baldwin, M, Nguyen, J, Gasset, M, Serban, A, Groth, D, Mehlhorn, I, Huang, Z, Fletterick, R J, Cohen, F E
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1993
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7902575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.10962
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