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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational process, no candidate chemical modification was identified, suggesting that a conformational change features i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pan, K M, Baldwin, M, Nguyen, J, Gasset, M, Serban, A, Groth, D, Mehlhorn, I, Huang, Z, Fletterick, R J, Cohen, F E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47901/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7902575/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.10962
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