Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

Prions are composed largely, if not entirely, of prion protein (PrPSc in the case of scrapie). Although the formation of PrPSc from the cellular prion protein (PrPC) is a post-translational process, no candidate chemical modification was identified, suggesting that a conformational change features i...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Pan, K M, Baldwin, M, Nguyen, J, Gasset, M, Serban, A, Groth, D, Mehlhorn, I, Huang, Z, Fletterick, R J, Cohen, F E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7902575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.10962
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