Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

Expression of the PD-1 receptor on T cells has been shown to provide an important inhibitory signal that down-modulates peripheral effector responses in normal tissues and tumors. Furthermore, PD-1 up-regulation on chronically activated T cells can maintain them in a partially reversible inactive st...

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Hlavní autoři: Goldberg, Monica V., Maris, Charles H., Hipkiss, Edward L., Flies, Andrew S., Zhen, Lijie, Tuder, Rubin M., Grosso, Joseph F., Harris, Timothy J., Getnet, Derese, Whartenby, Katharine A., Brockstedt, Dirk G., Dubensky, Thomas W., Chen, Lieping, Pardoll, Drew M., Drake, Charles G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896112/
https://ncbi.nlm.nih.gov/pubmed/17392506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-062422
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