Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

Expression of the PD-1 receptor on T cells has been shown to provide an important inhibitory signal that down-modulates peripheral effector responses in normal tissues and tumors. Furthermore, PD-1 up-regulation on chronically activated T cells can maintain them in a partially reversible inactive st...

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Detalhes bibliográficos
Main Authors: Goldberg, Monica V., Maris, Charles H., Hipkiss, Edward L., Flies, Andrew S., Zhen, Lijie, Tuder, Rubin M., Grosso, Joseph F., Harris, Timothy J., Getnet, Derese, Whartenby, Katharine A., Brockstedt, Dirk G., Dubensky, Thomas W., Chen, Lieping, Pardoll, Drew M., Drake, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896112/
https://ncbi.nlm.nih.gov/pubmed/17392506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-062422
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