Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells

Lymphocyte Activation Gene-3 (LAG-3) is a transmembrane protein that binds MHC class II, enhances regulatory T cell activity, and negatively regulates cellular proliferation, activation, and homeostasis of T cells. Programmed Death 1 (PD-1) also negatively regulates T cell function. LAG-3 and PD-1 a...

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Main Authors: Grosso, Joseph F., Goldberg, Monica V., Getnet, Derese, Bruno, Tullia C., Yen, Hung-Rong, Pyle, Kristin J., Hipkiss, Edward, Vignali, Dario A. A., Pardoll, Drew M., Drake, Charles G.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082361/
https://ncbi.nlm.nih.gov/pubmed/19454660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804211
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