The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

Acute lymphoblastic leukemia (ALL) in adult patients is often resistant to current therapy, making the development of novel therapeutic agents paramount. We investigated whether mTOR inhibitors (MTIs), a class of signal transduction inhibitors, would be effective in primary human ALL. Lymphoblasts f...

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Main Authors: Teachey, David T., Obzut, Dana A., Cooperman, Jonathan, Fang, Junjie, Carroll, Martin, Choi, John K., Houghton, Peter J., Brown, Valerie I., Grupp, Stephan A.
格式: Artigo
語言:Inglês
出版: © 2006 by The American Society of Hematology 2006
主題:
Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895910/
https://ncbi.nlm.nih.gov/pubmed/16195324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1935
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