Tuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779

BACKGROUND: Tuberous Sclerosis Complex (TSC) is an autosomal dominant hamartoma disorder with variable expression for which treatment options are limited. TSC is caused by a mutation in either the TSC1 or TSC2 genes, whose products, hamartin and tuberin, function as negative regulators in the highly...

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Bibliographic Details
Main Authors: Messina, Michael P, Rauktys, Aubrey, Lee, Laifong, Dabora, Sandra L
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213639/
https://ncbi.nlm.nih.gov/pubmed/17986349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-7-14
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