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Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity. TSC is caused by mutations in the TSC1 or TSC2 genes, whose products, hamartin a...

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Bibliografiske detaljer
Main Authors: Lee, Nancy, Woodrum, Chelsey L, Nobil, Alison M, Rauktys, Aubrey E, Messina, Michael P, Dabora, Sandra L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670829/
https://ncbi.nlm.nih.gov/pubmed/19368729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-9-8
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